Looks like line 1 should be:

I had to set 'DatabaseDirectory /usr/local/homebrew/var/lib/clamav/' in both

and then
sudo chown _clamav /usr/local/homebrew/var/lib/clamav/

@flickerfly you shouldn't have to use sudo with brew package.

@lucascantor thanks I fixed this typo.

Thank you, this helped!

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This was very helpful, many thanks.

The initial scan takes forever.

I have an 1 TB drive, running on macOS Sierra 10.12.6.

brew link clamav fails on macOS High Sierra.

Had to run following commands to get ClamAV working:
sudo mkdir /usr/local/sbin
sudo chown -R $(whoami) $(brew --prefix)/* (standard brew fix does not work anymore on OS X 10.13)
brew link clamav

The OP worked as is for me, when the 'Example' was changed to 'FooClam' or similar (Anything =/= Example).
No other changes made to freschclam.conf.

Why is it the first time I had to install Clamav with such effort, and with brew?

All the other versions till Sierra were nicely installed without any need to configure with a nice UI and reporting to console.

thanks @flickerfly !

Thank you!

By default the database dir is /usr/local/share/clamav/, it is symlinked to Cellar/.. and get cleared on update. It might be a good idea to change DatabaseDirectory to /usr/local/var/lib/clamav in freshclam.conf & clamd.conf.

for Homebrew 2.2.2 on macOS 10.14.6 I found clamav symlink at
/usr/local/var/homebrew/linked/clamav